Heat oil in a frying pan over medium-high heat.
While the oil is heating whisk together flour, Italian seasoning, garlic powder, salt and pepper in a shallow bowl. Add water and mix until smooth.
Add part of the florets to the batter and toss to coat.
Dip florets in a pie pan filled with Panko.
Fry in the oil (until golden brown). Continue until all the florets are fried. Quickly toss (do not soak) florets in warm buffalo sauce.